P62 FUNDAMENTALS EXPLAINED

Oxidative tension triggers DNA harm in the nucleus and mitochondria. DNA fragments are then produced into your cytoplasm, wherever they induce p62-mediated selective autophagy by unique mechanisms as well as cGAS-STING-mediated DNA sensing innate immune pathway. The kinases ULK1 and TBK1 Enjoy twin roles in both of these pathways. ULK1 phosphorylat